➀ The review discusses skeletal interoception and its role in bone health; ➁ It highlights biomaterials designed to interact with this system for bone regeneration; ➂ The article explores studies on neural guidance and bone repair using engineered biomaterials; ➃ It emphasizes the importance of three-dimensional architecture and controlled release systems in biomaterial design for bone regeneration.

1. Researchers from the Chinese Academy of Sciences developed piezoelectric PLLA scaffolds with a bone-like microenvironment to promote bone regeneration in rats. 2. The scaffolds mimic mineralized collagen fibers and enhance osteogenic differentiation through ultrasonic-responsive piezoelectric signals. 3. This multifaceted bionic strategy offers a novel approach in bone tissue engineering.