➀ The review discusses skeletal interoception and its role in bone health; ➁ It highlights biomaterials designed to interact with this system for bone regeneration; ➂ The article explores studies on neural guidance and bone repair using engineered biomaterials; ➃ It emphasizes the importance of three-dimensional architecture and controlled release systems in biomaterial design for bone regeneration.

1. Researchers from the Chinese Academy of Sciences developed piezoelectric PLLA scaffolds with a bone-like microenvironment to promote bone regeneration in rats. 2. The scaffolds mimic mineralized collagen fibers and enhance osteogenic differentiation through ultrasonic-responsive piezoelectric signals. 3. This multifaceted bionic strategy offers a novel approach in bone tissue engineering.

1、研究人员开发了一种光热复合骨架，以促进骨缺陷修复。该骨架含有光热敏感纳米材料SiO2@Fe3O4，能够诱导控制的内部温度变化，促进矿化分异和骨缺陷修复。 2、该骨架的制备使用生物三维打印技术，并添加了光热敏感纳米粒子Fe3O4。 3、研究结果表明，该骨架具有良好的机械强度和光热性能，可以在骨组织工程应用中促进骨缺陷修复。